Orphaned at an early age, Peter Parker (Tobey Maguire) lived in Queens with his beloved Aunt May (Rosemary Harris) and Uncle Ben (Cliff Robertson). Peter leads the life of a normal student, working as a photograph for the Daily Bugle, pining after the beautiful Mary Jane Watson (Kirsten Dunst), and hanging out with buddy Harry Osborn (James Franco). On a school trip, during which Peter and his classmates are given a science demonstration on spiders, Peter is bitten by a genetically-altered spider. Soon after, he discovers that he has unusual powers; he is endowed with the strength and agility of a spider along with a keen ESP-like "spider sense". After discovering these powers, Peter appears in a televised wrestling match and, armed with his new spider strength, wins the match in record time. But the wrestling match promoter refuses to award Peter the $3,000 prize money, alleging that Peter won too quickly. Soon afterwards, Peter has the opportunity to catch a burglar fleeing from the promoter's office, but because he wants revenge, he refused to stop him. Moments later, the same burglar kills his beloved Uncle Ben. As Spider-Man, Peter apprehends the burglar but is plagued with guilt for not being a hero sooner. Meanwhile, megalomaniacal businessman Norman Osborn (Willem Dafoe), Harry's father, is undergoing some changes of his own. An experimental formula has blown up in his face, increasing his intelligence and strength but also driving him insane. He is now the Green Goblin, Spider-Man's arch-enemy, who will put young Peter Parker's vow to fight crime and help innocent people to the ultimate test.
Story is courtesy of http://www.spiderman.sonypictures.com